After a decade as the anchor of "NBC Nightly News," Lester Holt is starting a new chapter in his journalism career. | USA TODAY Video

A man was killed during a brazen attack in New Jersey involving a crossbow, leading to an intense police standoff with the suspect. NBC News’ Emilie Ikeda has the latest. | NBC Nightly News with Tom Llamas

The Trump administration signaled other countries could be targeted after the massive military action in Venezuela. NBC News’ Gabe Gutierrez reports from Colombia. | NBC Nightly News with Tom Llamas

As recently as Friday President Trump was talking up efforts to find a negotiated solution to the U.S. tensions with Iran. NBC News’ Garrett Haake reports from the White House on the details that led to the unprecedented strike. | NBC Nightly News with Tom Llamas

Gov. Cuomo responds to President Trump, who said he doesn't believe New York needs 30,000 ventilators. "I hope no one needs a ventilator," Cuomo told Lester Holt today. "But I don't operate on what I hope...I operate on the data..." Watch the interview tonight on Nightly News. | NBC Nightly News with Tom Llamas

TONIGHT: Lester Holt interviews Dr. Anthony Fauci as the US adds travel restrictions in response to the Omicron Covid-19 variant. We'll have the latest tonight on NBC Nightly News at 6:30 ET / 5:30 CT (check your local NBC station listings). Read more: https://nbcnews.to/3p4LxV5 | NBC Nightly News with Tom Llamas

"One pill could kill. One pill, one time, game over." Tonight on NBC Nightly News, Lester Holt talks to Cheri Oz, Special Agent in Charge of the DEA's Phoenix Field Division, about the fentanyl crisis. Watch the full report at 6:30 pm ET / 5:30 pm CT (check local listings). | NBC Nightly News with Tom Llamas