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Patent Ductus Arteriosus (PDA) 🫀: Quick Facts PDA = ductus arteriosus stays open after birth Causes: ↑PGE2, low O₂, genetics Left-to-right shunt → ↑lung blood flow Small: silent or soft murmur Large: heart strain, wide pulse, risk of pulmonary hypertension & cyanosis #PDA #Cardiology #HeartDefect #Pediatrics 🩺 | Abdallah Othman
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How Inflammation Triggers a Fever 🔥 When your body detects infection or injury, immune cells release pro-inflammatory cytokines like IL-1, IL-6, and TNF-α. 🧠 These travel to the hypothalamus, your body’s thermostat, and stimulate production of prostaglandin E2 (PGE2). 🔥 PGE2 raises the hypothalamic set point, telling your body to generate and conserve heat — leading to shivering, vasoconstriction, and ultimately… fever. ✅ Fever helps slow pathogen replication and boosts immune activity. #meds
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