Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and multifunctional, and together, act at nearly all membranes ...

Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K pathway-targeted therapies have been tested in oncology trials, ...

The phosphoinositide 3-kinase (PI3K) pathway is frequently activated in human cancer and represents an attractive target for therapies based on small molecule inhibitors. PI3K isoforms play an essential role in the signal transduction events ...

Phosphoinositide 3-kinase (PI3-K) is a dual-specificity kinase with lipid and protein kinase activity. One of its targets is the protein kinase B (PKB or Akt) [89]. The PI3-K/PKB pathway has been shown to deliver an anti-apoptotic signal [90–92], which is negatively regulated by the lipid and protein phosphatase PTEN, a tumour suppressor gene [93].

Nov 14, 2022 · Although extensive efforts have focused on drugging class I phosphoinositide 3-kinases (PI3Ks), recent years have revealed opportunities for targeting almost all phosphoinositide kinases in human...

Phosphoinositide 3-kinase (PI3K) is a crucial regulator involved in cellular functions such as proliferation, survival, and metabolism. It is often implicated in various human diseases and is a target for drug development in both academic and pharmaceutical research.

Phosphoinositide 3-kinase (PI-3 kinase) belongs to a family of lipid kinase enzymes of which there are four classes (IA, IB, II and III) based on their in vitro substrate specificities, and there activation by various receptors (e.g., cytokine, growth hormone, Toll, G-protein coupled).

May 31, 2002 · The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted.

Feb 23, 2012 · Phosphoinositide 3-kinases (PI3Ks) generate intracellular lipids that affect a range of cell biological phenomena. They phosphorylate the 3-OH group of inositol membrane lipids to modulate...