Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder worldwide, ...

IBD has become a global disease in the 21st century that shifts through four epidemiological stages. Alterations in the gut ...

Background Globally, an estimated 296 million individuals live with chronic hepatitis B virus (HBV) infection, carrying ...

The first report of pancreatic cancer in a patient with recent onset of diabetes was made in 1833.1 However, even today, the relationship between the two conditions remains poorly understood. Our ...

We read with great interest the review by Suo et al published in Gut recently, ‘Spatial single-cell omics: new insights into liver diseases’.1 This very well-written and comprehensive review ...

Background Autoimmune hepatitis (AIH) is characterised by death of hepatocytes and chronic inflammation. Patients with deleterious variants in A20 are identified with AIH presentations and immune ...

Background In the hepatitis B e antigen positive (HBeAg+) chronic infection disease phase, approved treatments have limited effects on hepatitis B surface antigen (HBsAg) and HBeAg. Objective The ...

Objective Patients infected with Helicobacter pylori develop chronic gastritis with a subgroup progressing to further complications. The role of microbiota from the oral cavity swallowed with saliva ...

A recent study by Erkert et al identified a new role for Alzheimer’s disease (AD)-associated presenilins as key molecules involved in maintaining intestinal epithelial function, barrier integrity and ...

Zhou and colleagues published an observational study on the beneficial effects of statin use in steatotic liver disease.1 Using a large, multicentre database, the author reported that statin use in ...

Objective To monitor trastuzumab resistance and determine the underlying mechanisms for the limited response rate and rapid emergence of resistance of HER2+ metastatic gastric cancer (mGC). Design ...

Timely detection of oesophageal adenocarcinoma (OAC) and even more so its precursor Barrett’s oesophagus (BO) could contribute to decrease OAC incidence and mortality. An accurate, minimally-invasive ...