The Israeli strikes in Iran have killed over 200 people and injured hundreds of others, Iran’s Health Ministry said Sunday. Human rights groups say the numbers are probably much higher. Iranian media reported explosions and heavy air defense fire in the capital of Tehran and explosions in the northwestern city of Tabriz on Tuesday.

Although Iran maintains that its nuclear program is for peaceful energy purposes, Israel has long seen it as a threat. Israeli strikes have hit three of Iran’s nuclear facilities — Natanz, Isfahan and Fordow. Little damage appears visible in satellite imagery of Fordow.

Iran’s embattled leaders have found themselves in an existential struggle domestically to protect nearly a half-century of rule.