For the dopaminergic neurons that are especially vulnerable in Parkinson’s disease, a glut of cholesterol may be a death sentence. That’s according to scientists led by Ming Lu and Lei Cao at Nanjing ...
Calling all lipid enthusiasts! Scientists have put together a three-dimensional map of where these molecules reside throughout the entire mouse brain. Using high-tech mass-spec imaging, researchers ...
Calling all lipid enthusiasts! Scientists have put together a three-dimensional map of where these molecules reside throughout the entire mouse brain. Using high-tech mass-spec imaging, researchers ...
As part of the mammalian innate immune response, the complement system evolved to fight off foreign microbes, and it also helps the brain stave off amyloid plaques. But are all proteins in this ...
Loss of the growth-control protein tuberin causes tuberous sclerosis, a neurodevelopmental disorder in which kids have astrocytosis and suffer seizures. Do the latter cause the former? To find out, ...
Research animals raised in cool environments live longer, but why is this so? In the October 21 Nature, scientists led by Hyun Ju Lee and David Vilchez at the University of Cologne, Germany, proposed ...
Genes: Plcg2, APP, PSEN1 Modification: Plcg2: Knock-In; APP: Transgenic; PSEN1: Transgenic Disease Relevance: Alzheimer's Disease Strain Name: N/A Genetic Background ...
To mark the 20th anniversary of Alzforum's launch in 1996, we have compiled a timeline reflecting the evolution of Alzheimer’s disease research, starting from Alois Alzheimer's public presentation of ...
The competition supports research projects that develop and implement Artificial Intelligence (AI) and technology approaches to improve the health and well-being of older adults, including people ...
Score another one for amyloid immunotherapy. The anti-pyroglutamated amyloid antibody donanemab has posted positive top-line results in the Phase 3 Trailblazer-Alz2 study, according to an Eli Lilly ...
Transferrin-receptor shuttles distribute antibody cargo throughout the parenchyma, steering clear of ARIA-provoking vascular amyloid. Trontinemab is enrolling Phase 3 for early AD, announces plans for ...
The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous ...
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