This important study advances the HIV-1 vaccine development field by establishing six humanized immunoglobulin knock-in mouse models to facilitate the design and evaluation of HIV-1 vaccines. The ...

Neuropeptides mediate inter-tissue communication in energy metabolism, yet most remain functionally uncharacterized. Using C. elegans, we uncover a neuropeptide signaling cascade that drives lipid ...

The authors use a modeling approach to examine the effects of local and global perturbations on the electrophysiological properties of astrocytes: their modeling results suggest that local ionic ...

Laboratory of Neural Computation, Institute for Quantitative Biosciences, the University of Tokyo, Tokyo, Japan Department of Life Sciences, Graduate School of Arts and Sciences, the University of ...

This important manuscript reports exceptionally preserved, millimeter-scale segmented bilaterian microfossils from the early Cambrian Fortunian Kuanchuanpu Formation in South China. The authors ...

chaining is more likely when the experiences to be integrated are relatively familiar (greater number of exposures) and ordered in a manner that promotes encoding of the associative links that are ...

We used correlative light and focussed ion beam–scanning electron microscopy (FIBSEM) to characterise the ultrastructural organisation of neuromodulatory axons in the upper layers of the adult mouse ...

Lymphatic vessels beat faster as they fill with fluid through a chain of calcium signaling, though the first pressure sensor ...

In the presence of emulated cone loss, eye movements are used to gather and integrate information, leading to improved letter ...

Diverse combinations of glutamate receptor subunits are expressed across developmental stages and even between adjacent ...

Microfossils from the Paleoarchean Eon are the oldest known evidence of life. Despite their significance in understanding the history of life on Earth, any interpretation of the nature of these ...