England vice-captain Jamie George has been ruled out of the Six Nations opener against defending champions Ireland on February 1, the Rugby Football Union announced on Tuesday.

Vice-captain Jamie George heads England withdrawals for Six Nations opener - Influential scrum-half Alex Mitchell is a doubt for the opener against Ireland on February 1.

England lose Jamie George for Six Nations opener as injuries mount before Ireland clash - Alex Mitchell is also doubtful for Dublin trip, with Alex Coles, Jack van Poortvliet and Alex Dombrandt all ru

Jamie George’s miserable week was compounded when the hooker limped off with a hamstring problem late in Saracens’ Champions Cup defeat by Castres.

England have suffered significant injury news ahead of the Six Nations with Jamie George set to miss their opening fixture against Ireland. Hooker George, who has been replaced by Maro Itoje as captain,

Former England captain Jamie George is now a major injury doubt for the Six Nations after picking up a knock in Saracens’ shock 32-24 defeat to Castres last night. George was named England skipper ahead of last year’s Championship,

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.