Despite potential benefits, the therapy remains in limited use for myeloproliferative neoplasms (MPNs). Pegylated interferons are a meaningful therapeutic option for the treatment of ...

In 1980, TIME Magazine wrote about interferon as the “if” drug for cancer. Promising studies sparked widespread hope around the potential of the interferon to treat cancer, only if it could deliver ...

Innate immune sensors—known as pattern recognition receptors (PRRs)—detect specific molecular components of bacterial or ...

These intercellular messages, ferried about by molecules called interferons, serve as a warning signal to nearby cells—“‘You are about to be infected; it’s time for you to set up an antiviral state,’” ...

A team led by researchers at the University of Cologne has identified a protein called ANKIB1 that acts as a volume dial for the body’s frontline immune defenses, controlling how strongly cells ...

In a recent study published in Science Immunology, researchers investigated whether individuals with breakthrough infections of severe coronavirus disease 2019 (COVID-19) pneumonia demonstrated normal ...

CHICAGO — The use of a clinically validated flow cytometry test can assess type 1 and type 2 interferon activity in children with various pediatric inflammatory diseases to evaluate and monitor their ...

A new study shows that about two percent of the population develop autoantibodies against type 1 interferons, mostly later in life. This makes individuals more susceptible to viral diseases like COVID ...

Researchers have examined five SARS-CoV-2 variants to determine how each strain interacts with the innate arm of the immune system -- the first line of defense in the immune system versus the antibody ...