NFL Week 6 betting spreads, lines, point totals for every game on the NFL Week 6 schedule, with odds for favorites and underdogs in each NFL matchup.

Our expected Week 6 First Touchdown scorers include Josh Jacobs, Ashton Jeanty and Davante Adams! Week 6 of the NFL season is here, and we have some great matchups on Sunday.

Read below for picks on every Week 6 game. Lines are the best currently available in Las Vegas on the chosen side. Picks are labeled in three separate confidence categories — plays, leans and guesses — and listed in rough order of conviction. The overall record for the season now sits at 43-32-3.

Kellen Moore's team hit on a rare explosive play with an 87-yard bomb from Spencer Rattler to Rasheed Shaheed -- take that long score out and New Orleans averaged just 4.0 yards per play against a questionable Giants defense. New York handed the Saints three pretty unacceptable fumbles as well.

The Jacksonville Jaguars are riding high off their Monday Night Football win over the Kansas City Chiefs. Can they keep the good times rolling against the Seattle Seahawks? Trevor Lawrence tripped his way into a 31-28 win last week to get the Jags to 4-1.

While the Las Vegas Raiders were on a bye during Week 8, they did get some help when it comes to their odds to get the No. 1 overall pick in the 2026 NFL draft. With the New York Jets pulling off a comeback against the Cincinnati Bengals,

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 41-21 run on top-rated picks dating back to 2024.