Week 8 of the 2025 NFL season features a few intriguing lines, and Athlon Sports’ NFL experts are here with their best bets. While I went 2-1 last week, it was the loss stood out to me — because I was basing that pick on an anomaly in our red zone plus/minus metric.

07 – Indianapolis at LA Chargers Daniel Jones is thriving behind a competent offensive line, completing 71.7 percent of his passes and averaging 250 yards per game. Both marks are career bests. His improved play should challenge a Chargers defense that has struggled to contain efficient quarterbacks. Winner: Indianapolis