Who will miss the Louisville Cardinals' Week 10 ACC college football game vs. Virginia Tech? Here's the latest Louisville football injury report.

Isaac Brown rushed for 130 yards and a touchdown before leaving late with a leg injury and Keyjuan Brown scored twice in the second half to lift No. 16 Louisville to a 28-16 victory over Virginia Tech.

Virginia Tech football is now less than 24 hours from kicking off against the No. 16 Louisville Cardinals. Here are my three keys to victory for the Hokies to potentially walk out of Lane Stadium with a fourth win of 2025.

For about 30 minutes on Saturday afternoon, it looked like the Virginia Tech Hokies were about to win their second game in a row and move to 3-2 in ACC play. Unfortunately, a lopsided third quarter changed everything, and the No. 16 Louisville Cardinals (7-1, 4-1) came from behind to defeat the Hokies 28-16 (3-6, 2-3).

The Hokies offensive line continuously opened holes for leading rusher Marcellous Hawkins, who gained 167 yards on 21 carries in a win against Cal.

Only a quartet of contests remain for Virginia Tech football in its 2025 campaign. Through a turbulent campaign, the Hokies have notched three wins and will need to claim as many over the next month to qualify for a bowl game this season.

Preview the Week 9 NCAA football matchup between the Virginia Tech Hokies and California Golden Bears with a prediction, pick, odds and more.

Kickoff from Lane Stadium in Blacksburg, Va., is at 7:30 p.m. ET. The Hokies are 6.5-point favorites in the latest California vs. Virginia Tech odds, while the over/under for total points scored is 50.5. Before making any Virginia Tech vs. California picks, check out the college football predictions from the SportsLine Projection Model .

Louisville comes to Lane as a 10.5 point favorite, and a waning spirit for the season on the part of the Hokies who are in personal salvage mode, now.