New drug discovery is a critical step for improving patients' lives. First, researchers must identify molecules in the body's cells that help drive disease, as these are potential targets for new ...
SlimVar is a 2D+ time imaging technique which identifies fluorescent foci from local intensity maxima in each video frame (Fig. 1, Table 1). Foci correspond to at least one, or more generally, a ...
Membrane protein dynamics regulates cell functions by initiating downstream signaling cascades. The cell membrane is compartmentalized into nanodomains by actin structures, restricting lateral protein ...
A team has developed a large-scale drug screening technique that can track target molecule behavior within cells. The researchers verified their technique by testing the epidermal growth factor ...
Sample Preparation: The protocol emphasizes the importance of fluorescent labeling of proteins of interest (POIs) through genetic insertion of fluorescent proteins (FPs) or self-labeling protein tags ...
Using a powerful single-molecule imaging method they developed, a Broad Institute research team has unveiled a dynamic view of how some cancer-related proteins interact in living cells. The technique ...
New drug discovery is a critical step for improving patients' lives. First, researchers must identify molecules in the body's cells that help drive disease, as these are potential targets for new ...
Top) Drug screening with automated system for in-cell single-molecule imaging. Bottom) Diffusion coefficient of the receptor (left) and cluster formation (right) were measured from 1,000 cells. These ...
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