Months or even two or three years after the onset of Raynaud's phenomenon, people with the systemic form of scleroderma usually notice swelling of the hands with an uncomfortable tight sensation. That ...

Scleroderma is an autoimmune condition that causes the skin to become tight and hard. This can change facial appearance, such as the mouth becoming smaller, and affect internal organs. With ...

Scleroderma is a rare disease in which a person's immune system begins to destroy normal, healthy tissues. (This is called an autoimmune disease.) As a result, connective tissue of the skin, lungs, ...