One of the most expensive steps in manufacturing protein drugs such as antibodies or insulin is the purification step: isolating the protein from the bioreactor used to produce it. This step can ...

Tedious, time-consuming, exasperating: Those are perhaps the three words that researchers use most commonly to describe protein purification. Proteins, and their little sisters the peptides, are among ...

Affinity chromatography has revolutionized protein purification in many areas, from basic research up to biotechnological and biopharmaceutical applications. In this technique, a specific ligand or ...

The isolation of proteins in high yield and purity is a major bottleneck for the analysis of their three-dimensional structure, function and interactome. Here, we present a streamlined workflow for ...

Effective and efficient protein purification processes are essential in drug discovery and development. Affinity fusion tags are commonly used in protein purification due to their ability to enable ...

For the novice protein purifier, finding a place to start might seem overwhelming, but fortunately the process can be approached systematically. Andrew Mitchell, technical consultant for Amersham ...

Bed-height Optimization Can Reduce Cost and Increase Speed of Production Affinity chromatography is potentially the most selective method for protein purification and is often included as a primary ...

Proteins play a key role in the life sciences - from basic research and biotechnological applications to the development and manufacturing of pharmaceuticals. Scientists at the Technical University of ...

Creating analytical tools that support the advancement of knowledge can often come about through the integration of existing information and techniques, theoretical and practical, directed toward a ...

Correlative cryo-light microscopy and cryo-FIB workflows improve the localization and preparation of intracellular crystals ...

Engineers devised a way to purify protein drugs during manufacturing. Their approach, which uses nanoparticles to rapidly crystallize proteins, could help make protein drugs more affordable and ...