“People have always been after the silver bullet against cancer and there are few things that are as relevant across cancer types as p53. Now the question is what is the best approach to harness it,” ...

Under normal, unstressed conditions, a key negative regulator of p53 is MDM2, which binds to the transactivation domain of p53 and ubiquitylates the protein, targeting it for degradation. [21] Because ...

In response to varying stress signals, the p53 tumor suppressor is able to promote repair, survival, or elimination of damaged cells – processes that have great relevance to organismal aging. Although ...

Researchers at Cold Spring Harbor Laboratory (CSHL) say they have discovered that a protein known as BRD8 may represent a previously unknown vulnerability in the deadly brain cancer glioblastoma (GBM) ...

There are two important categories of genes involved in cancer development, oncogenes and tumor suppressor genes. When oncogenes gain function, e.g. through mutation, they actively promote cancer - ...