Like a plug and a socket, a nerve and a muscle fiber mesh at the neuromuscular junction. New work reveals that an extracellular matrix protein called laminin shapes both sides of the junction to ...

Aarhus, Denmark, 1 March 2024 – NMD Pharma A/S, a clinical-stage biotech dedicated to developing novel and improved treatments for patients living with neuromuscular diseases, today announces that it ...

Among stem cell biologists there are few better-known proteins than nestin, whose very presence in an immature cell identifies it as a "stem cell," such as a neural stem cell. As helpful as this is to ...

A synthetic optoelectronic synapse between an artificial neuron and muscle. (Courtesy: Yeongjun Lee) Researchers in Korea and the US have engineered a light-activated synthetic synapse that enables an ...

CAMBRIDGE, Mass. -- Harvard University researchers have uncovered a mechanism through which caloric restriction and exercise delay some of the debilitating effects of aging by rejuvenating connections ...

The muscle-specific receptor tyrosine kinase (MuSK) is part of a receptor complex, activated by neural agrin, that orchestrates the differentiation of the neuromuscular junction (NMJ). To gain insight ...

The muscle transmembrane protein Vangl2 helps organize the development and maintenance of connections between muscles and motor neurons, a study concludes. A skeletal muscle isn’t much use without a ...

The neuromuscular junction - where nerves and muscle fibers meet - is an essential synapse for muscle contraction and movement. Improper function of these junctions can lead to the development of ...

The aggregating protein called agrin is a component of two quite different types of synapses: synapses in the neuromuscular junction and the immunological synapse between T cells and ...

Synaptic connections are made and broken in an activity-dependent manner in diverse regions of the nervous system. However, whether activity is strictly necessary for synapse elimination has not been ...

Like a plug and a socket, a nerve and a muscle fiber mesh at the neuromuscular junction. New work by Nishimune et al published in the Journal of Cell Biology reveals that an extracellular matrix ...