After a wild Week 9 brought another round of big coaching changes in college football, it's time to shift our attention forward to Week 10 with some early predictions for this week's biggest games. The Week 10 slate features a trio of ranked matchups and some of the nation's best getting important tests in conference play.

All eyes will be on the SEC today, which features the only three top-25 matchups of Week 9.

Mike Marteny's DraftKings daily fantasy college football lineup picks for the Saturday (10/25/25) main slate in Week 9. His CFB DFS lineup picks and DFS sleepers will help you win.

Mississippi State nearly pulled off the win over Texas in Week 9 as one of our bold bets, but we did correctly back Houston as a spread underdog against Arizona State. Which teams will we be looking at for Week 10 of the college football season when it comes to making bold bets?