Chromosomes have to be organized into three-dimensional structures from loose tangles, through a process called loop extrusion. It had been proposed that a protein complex named cohesin was probably ...

A human cell carries in its nucleus two meters of spiraling DNA, split up among the 46 slender, double-helical molecules that are its chromosomes. Most of the time, that DNA looks like a tangled ball ...

Entropic forces have been argued to drive bacterial chromosome segregation during replication. In many bacterial species, however, specifically evolved mechanisms, such as loop-extruding SMC complexes ...

Abstract: Cells of the human body contain long molecules of DNA, 2 meters in each cell. It has been almost 20 years since the human genome was sequenced, but only now we are starting to understand why ...