Ageing is a complex and multifaceted process, resulting in functional decline and heightened vulnerability to diseases across various organ systems and tissues. Notably, the immune and skeletal ...

Panelists discuss how immunoglobulin A (IgA) nephropathy develops through a complex 4-hit cascade involving aberrant IgA1 glycosylation, anti-glycan antibody formation, immune complex deposition, and ...

It has only recently become known that two parallel systems of blood formation exist in the body, originating from different precursor cells. Researchers at the German Cancer Research Center (DKFZ) ...

Immunoglobulin A (IgA) nephropathy is an autoimmune disease characterized by the deposition of circulating IgA-containing immune complexes (IgA-ICs) in the glomerular mesangium, leading to mesangial ...

Myddosome is an oligomeric complex required for the transmission of inflammatory signals from TLR/IL1Rs and consists of MyD88 and IRAK family kinases. However, the molecular basis for the ...

Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) is a rare disease that affects the filtering units in your kidneys (glomeruli). There are many types of glomerular diseases.

Kidney Disease: Improving Global Outcomes (KDIGO) has issued comprehensive, evidence-based recommendations for clinicians managing immunoglobulin A nephropathy (IgAN) and immunoglobulin A vasculitis ...

A new LMU study shows how differently immune cells influence the formation of dangerous vascular deposits - and identifies miR-147 as a potential starting point for future therapies. The heart and ...

Gastrointestinal (GI) malignancies—including esophageal, gastric, colorectal, hepatic, and pancreatic cancers—constitute a major global health burden and ...

Many vaccines work by introducing a protein to the body that resembles part of a virus. Ideally, the immune system will produce long-lasting antibodies recognizing that specific virus, thereby ...

A new study developed a mineralized DNA hydrogel that combines immune regulation with sustained bone regeneration. Using ...