Interferon beta remains a cornerstone disease-modifying therapy in relapsing forms of multiple sclerosis. However, its utility is compromised by immunogenicity, whereby patients develop anti-drug ...

TLR4 recognizes bacterial-derived lipopolysaccharides and activates IRF3 via the adapter protein TRIF, contributing to the induction of type I IFN genes. Within endosomes, TLR3, TLR7, and TLR9 ...

[18F]Fluorodeoxyglucose Positron Emission Tomography Predicts Outcome for Ewing Sarcoma Family of Tumors To evaluate the safety of sequentially administered recombinant (r) human (h) interleukin-12 ...

Why does the COVID-19 virus make some people sicker than others? For years, scientists have looked to a critical piece of immune system machinery - known as the interferon pathway - for answers. There ...