BioWorld

IFNα-like small molecules successfully inhibit HBV replication

It’s known that interferon-alpha (IFNα) activates interferon-stimulated genes (ISGs) and disrupts the hepatitis B virus (HBV) replication cycle. Pegylated (PEG)-IFNα has been widely used for its ...
EurekAlert!

The relationship between viral replication and the severity of hepatic necroinflammatory damage changed before HBeAg loss in patients with chronic hepatitis B virus infection

Two cross-sectional, one validation cohort, and meta-analyses were used to explore the relationship between HBV replication and liver inflammation. Spearman analysis, multiple linear regression, and ...
News Medical

Paclitaxel treatment found to directly promote HBV replication and transcription

Hepatitis B virus (HBV) reactivation is commonly observed in individuals with chronic HBV infection undergoing antineoplastic drug therapy. Paclitaxel (PTX) treatment has been identified as a ...
EurekAlert!

Paclitaxel-induced immune dysfunction and activation of transcription factor AP-1 facilitate Hepatitis B virus replication

Hepatitis B virus (HBV) reactivation is commonly observed in individuals with chronic HBV infection undergoing antineoplastic drug therapy. Paclitaxel (PTX) treatment has been identified as a ...
News Medical

Rare bacterial strain yields groundbreaking compounds to combat hepatitis B

Scientists at the Institute of Microbial Chemistry, Japan, have isolated selective antiviral compounds from a rare bacterial strain to target hepatitis B virus. The study is published in The Journal ...
The American Journal of Managed Care

Bepirovirsen for Chronic Hepatitis B Receives Breakthrough Therapy Designation, Priority Review

FDA regulatory momentum includes priority review and breakthrough therapy designation for a potential first-in-class CHB functional cure, with a PDUFA target date of October 26, 2026. Current ...