A new review highlights how human evolution has shaped the presence of pathogenic variations in DNA damage repair (DDR) genes, offering a new perspective on why modern populations face increased ...

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that ...

Genomic instability is a defining hallmark of cancer, underpinning tumor initiation, evolution, and progression. Increasingly, genomic instability itself is recognized not merely as a consequence of ...

Cancer cell DNA doubling — when cells accidentally duplicate all chromosomes without dividing — now has a new risk factor: ...

DNA repeats—ranging from tandem microsatellites to interspersed transposon-derived elements and inverted palindromes—constitute a significant fraction of eukaryotic genomes. Their propensity to adopt ...

Scientists at Children's Medical Center Research Institute at UT Southwestern (CRI) have discovered that large pieces of DNA ...

A study led by Dr Jason Pitt, Principal Investigator at the Cancer Science Institute of Singapore (CSI Singapore), has ...

This article was published in Scientific American’s former blog network and reflects the views of the author, not necessarily those of Scientific American All cancers share ten underlying principles, ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...

Bacterial cells are prokaryotic and basic, and carry biomolecules like proteins and DNA encased in a cellular membrane. Cells ...

Researchers at The University of Texas MD Anderson Cancer Center have discovered a new blood-based biomarker that can help identify and characterize asymptomatic people with Lynch Syndrome (LS) who ...