Many cancers can be treated by administering DNA-damaging agents, such as platinum-based chemotherapy, because the resulting DNA damage causes the cancer cells to die. A subset of cancers, however, ...

DNA mismatch repair (MMR) is a conserved pathway that preserves genome integrity by recognising and correcting base–base mismatches and insertion–deletion loops arising during replication and ...

The data showed elevated levels of the metabolite αKG improved DNA repair, and blocking it made the cancer cells more sensitive to treatment.

Researchers found that cancer cells may repair chemotherapy-induced DNA damage, helping explain treatment resistance in ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal metabolic processes or external stressors such as radiation or chemical ...

DNA sits in sunlight every day, absorbing ultraviolet radiation that can set off the kind of chemical changes linked to ...

The APOE2 gene variant protects against Alzheimer's by enhancing DNA repair and preventing neuronal senescence.

RNA is one of the bodies most vital molecules, and it comes in a few forms. For example, messenger RNA fills an essential role in gene expression by copying the sequences of active genes, which are ...

The human genome is contained within the nucleus of cells. The genome is well protected, but many things can cause DNA damage, including aging, some drugs, and environmental factors like UV rays or ...

The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...

While the central dogma of molecular biology outlines the linear flow of genetic information from DNA to RNA to proteins (black lines), glycomics introduces a “3rd code of life”—glycans—that operates ...