Nature

Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures

Large-scale biobanks integrating genomic and electronic health record data enable genome-wide association studies (GWAS) to identify numerous genetic associations and provide insights into the ...
Nature

Multi-cohort machine learning identifies predictors of cognitive impairment in Parkinson’s disease

Multi-cohort analyses were conducted to improve model robustness and overcome single-cohort limitations, assessing hold-out test set performance (for more detailed statistics, including ...
ascopubs.org

Using Dose-Escalation and -Expansion Cohort Study as Pivotal Trial for Targeted Anticancer Drug Approval

BRCA1-Associated Protein 1 and Enhancer of Zeste Homolog 2: Pathway Interaction and Therapeutic Intervention in Breast Cancer, Mesothelioma, and Lymphoma Early-phase clinical trials (EPCTs) have been ...
Open Heart

Racial trends in outcomes and access to treatment for mitral regurgitation: a South London population cohort study

Background Racial disparities in valvular heart disease are well-documented, yet evidence specific to mitral regurgitation ...
BMJ Open

Use of medicinal herbs in an Iranian population: cross-sectional findings from the Fasa PERSIAN Cohort Study

Objectives To determine the prevalence, patterns and correlates of medicinal herb use in a rural Iranian population and to ...
BMJ

Joint non-linear dose–response associations of device-measured physical activity and cardiorespiratory fitness with cardiovascular disease: a cohort and Mendelian ...

Objectives To characterise the non-linear joint dose–response relationship of accelerometer-measured moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF, estimated as ...