DNA repair protein gene gone rogue may unlock new cancer treatments

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that ...
Medical Xpress

New patterns in cancer genetics point at tumor suppressor genes as potential therapeutic targets

Cancer is caused by genetic changes that occur in our cells over time. There are two main types of changes, namely somatic mutations, which are alterations in the DNA sequence, and copy number ...
Science Daily

Mechanism of drug reactivating tumor suppressors

Researchers have revealed the mechanism of the drug valemetostat shown to be effective in treating certain types of cancer by targeting a protein modification (histone methylation) silencing the ...
ascopubs.org

Chromosomal instability in tumor suppressor genes–altered prostate cancer.

Plasma proteome-based integrative prognostic nomogram in metastatic castrate-resistant prostate cancer (mCRPC). Transcriptional profiling of patients with metastatic hormone-sensitive prostate cancer ...
EurekAlert!

Aumolertinib plus chemotherapy improves progression-free survival in NSCLC with EGFR and concomitant tumor suppressor genes: ACROSS 2 phase III study

Contact: Chris Martin, MPH IASLC Media Relations cmartin@davidjamesgroup.com (Barcelona, Spain September 7, 2025, 10:45 a.m. CEST / UTC +2) – New results from the ACROSS 2 Phase III trial demonstrate ...
ascopubs.org

Integrating aggressive variant prostate cancer–associated tumor suppressor genes (AVPC-TSG) status to refine prognosis and predict androgen-receptor pathway inhibitors (ARPI ...

g-Rate–based machine learning model to predict overall survival (OS) in patients with metastatic prostate cancer (mPC) while on treatment.
C&EN

Prime editing suppressor transfer RNAs for gene therapy

A 3D illustration of a transfer RNA molecule hovering over a messenger RNA. Transfer RNA acts as an adaptor to convert messenger RNA codons into amino acids during protein synthesis. Credit: ...