The mutant protein that causes Huntington disease blocks axonal traffic by putting the molecular equivalent of the wheel-locking “boot” on motor proteins, according to a paper published online June 14 ...
Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known ...
Neurons, with their large cell bodies and extensive processes, depend on a delicately balanced intracellular transport machinery to keep in touch with their own outer reaches. Inequalities between ...
(Medical Xpress)—Neurons have developed elaborate mechanisms for transporting critical components, like transmitter-laden vesicles, down their axons to the synaptic terminations. An axon in a blue ...
Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...
We describe a strategy for analyzing axonal transport of cytosolic proteins (CPs) using photoactivatable GFP—PAGFP—with modifications of standard imaging components that can be retroactively fitted to ...
RNA granules, sites for the storage, transport, and regulation of RNA molecules within cells, are transported along axons and then translated locally, far from the cell body. Recent studies suggest ...
Huntington's disease is a genetic neurodegenerative disorder caused by mutations in the protein huntingtin and characterized by involuntary dance-like movements, severe behavioural changes and ...
Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.
Some results have been hidden because they may be inaccessible to you
Show inaccessible results