Allostery is a fundamental mechanism of biological regulation, in which binding of a molecule at a distant location affects the active site of a protein. Allosteric sites provide targets to fine-tune ...

Drug hunters have spent years cutting chemical keys to fit the most obvious biological locks: a protein’s active site, the spot where its natural substrate clicks in to turn it on or off. Walk into ...

RNA transcripts containing the hammerhead ribozyme have been engineered to self-destruct in the presence of specific nucleoside 3′,5′-cyclic monophosphate compounds. These RNA molecular switches were ...