Science word of the day: Allele, know its meaning, who introduced the term, and its practical applications

Download the TOI app now!What is the definition of the word "allele"Allele (noun): One of two or more alternative forms of ...
Nature

Allele-specific analysis of DNA replication origins in mammalian cells

The mechanisms that control the location and timing of firing of replication origins are poorly understood. Using a novel functional genomic approach based on the analysis of SNPs and indels in phased ...
ascopubs.org

ALLELE: A consortium for prospective genomics and functional diagnostics to guide patient care and trial analysis in newly-diagnosed glioblastoma.

Phase 1 study of AG-881, an inhibitor of mutant IDH1/IDH2, in patients with advanced IDH-mutant solid tumors, including glioma. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I.
ascopubs.org

Analysis of BRAF and KRAS mutations in colorectal cancer and rectal carcinogenesis via fluorescent allele-specific PCR.

Biomarker study in rectal cancer patients after 5FU-based radiochemotherapy: Evaluation of the prognostic capacity of thymidylate synthase in pretreatment biopsies and resected adenocarcinoma.