The current study shows that cells with additional chromosomes have an altered mitochondrial structure and function. The reason: mitochondrial precursor proteins are sequestered in p62-positive ...

I still recall my disappointment one day in 2015. I received the tumor DNA sequencing results for one of my patients, whose cancer had spread from her lungs to her brain. I saw not a single genetic ...

The above representative microscope images showcase ultra-fine bridges, a kind of abnormal link between chromosomes that causes catastrophic genetic instability. These bridges, composed of entangled ...

JA Rosenfeld is an employee of Signature Genomic Laboratories, a subsidiary of PerkinElmer, Inc. The authors have no other relevant affiliations or financial involvement with any organization or ...

Share on Facebook. Opens in a new tab or window Share on Bluesky. Opens in a new tab or window Share on X. Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window Chromosome 1 ...

Chronic myeloid leukemia (CML) is a type of blood cancer. CML is Philadelphia chromosome-positive (Ph+) when pieces of chromosomes 9 and 22 break off and swap places. This creates a new abnormal ...

Nearly half the embryos studied underwent developmental arrest because of genetic mishaps in early development—a revealing insight that suggests more IVF babies could come to term with changes in the ...

It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances ...

Multiple myeloma is a type of blood cancer that forms in plasma cells, white blood cells that produce infection-fighting antibodies. Multiple myeloma is not hereditary, meaning it is not passed down ...