Butterworth, also known as Gcuwa, is a town in the Eastern Cape Province, South Africa. Butterworth has a population of 45,900 and i…Butterworth, also known as Gcuwa, is a town in the Eastern Cape Province, South Africa. Butterworth has a population of 45,900 and is situated on the N2 national highway 111 km north of East London. The area around Butterworth was populated by amaXhosa, KhoiKhoi and San people.